GSM1046495[Accession] - GEO DataSets

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Items: 4

Select item 2000656771.

The Six1 oncoprotein represses translation of p53 via concomitant regulation of RPL26 and microRNA-27a

(Submitter supplied) TP53 is mutated in 50% of all cancers, and is often functionally compromised in cancers where it is not mutated. We demonstrate that the pro-tumorigenic/metastatic Six1 homeoprotein decreases p53 levels through a mechanism that does not involve the negative regulator of p53, MDM2. Instead, Six1 regulates p53 via a dual mechanism involving upregulation of microRNA-27a and downregulation of the ribosomal protein L26 (RPL26), a positive regulator of p53 translation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

5 related Platforms
377 Samples

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Accession:: GSE65677

ID:: 200065677

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000426402.

Transcriptomic Classification of Genetically Engineered Mouse Models of Breast Carcinoma Identifies Human Subtype Counterparts

(Submitter supplied) Background: Human breast cancer is a heterogeneous disease consisting of multiple molecular subtypes. Genetically engineered mouse models (GEMMs) are useful resources for studying breast cancers in vivo under genetically controlled and immune competent conditions. Identifying murine models with conserved human tumor features will facilitate etiology determinations, highlight the effects of mutations on pathway activation, and improve preclinical drug validation. more...

Organism:: Mus musculus

Type:: Expression profiling by array

4 related Platforms
110 Samples

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Series

Accession:: GSE42640

ID:: 200042640

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000028813.

Agilent-013326 Mouse Oligo Microarray (V2) G4121B (Feature Number version)

(Submitter supplied) Consisting of highly-sensitive 60-mer oligonucleotide probes that target human genes present in Incyte LifeSeq Foundation partial sequence database, the Agilent Human 1B Oligo Microarray Kit queries more rare human transcripts where full-length information is not available. The microarray is fully annotated to allow customers to access public or Incyte LifeSeq databases for additional bioinformatics data about the genes. more...