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Items: 3

1.

EZH2 is required for germinal center formation and somatic EZH2 mutations promote lymphoid transformation

(Submitter supplied) The EZH2 histone methyltransferase is highly expressed in germinal center (GC) B-cells and targeted by somatic mutations in B-cell lymphomas. Here we find that EZH2 deletion or pharmacologic inhibition suppresses GC formation and functions in mice. EZH2 represses proliferation checkpoint genes and helps establish bivalent chromatin domains at key regulatory loci to transiently suppress GC B-cell differentiation. more...
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL13112 GPL11154 GPL10999
61 Samples
Download data: BED, TXT, WIG
Series
Accession:
GSE45982
ID:
200045982

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10547 Series
183607 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

SUDHL5 shEZH2 2

Organism:
Homo sapiens
Source name:
SUDHL5 cell line
Platform:
GPL11154
Series:
GSE45982
Download data: TXT
Sample
Accession:
GSM1129325
ID:
301129325

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db=gds|term=GSM1129325[Accession]|query=12|qty=3|blobid=MCID_672a380d098d4d34591d891d|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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