GSM1162041[Accession] - GEO DataSets

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Items: 4

Select item 2000478941.

Maintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL11002 GPL13112
22 Samples

Download data: BW

Series

Accession:: GSE47894

ID:: 200047894

PubMed Full text in PMC Similar studies

Select item 2000478922.

Maintenance of DNA methylation in embryonic stem cells depends on the histone H3K9 methyltransferases (K9 KO 5hmC-capture-seq)

(Submitter supplied) During mammalian development DNA methylation patterns need to be reset in primordial germ cells (PGC) and preimplantation embryos. However, many retro-transposons and imprinted genes are resistant to such global epigenetic reprogramming via hitherto undefined mechanisms. Here, we report that some of these sequences are immune to widespread erasure of DNA methylation in the mouse embryonic stem cells (mESCs) lacking de novo DNA methyltransferases. more...