GEO DataSets

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:

Mus musculus; Homo sapiens

Type:

Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array

5 related Platforms

70 Samples

Download data: CEL, TXT

(Submitter supplied) Topoisomerases are necessary for the expression of neurodevelopmental genes, and are mutated in some patients with autism spectrum disorder (ASD). We have studied the effects of inhibitors of Topoisomerase 1 (Top1) and Topoisomerase 2 (Top2) enzymes on mouse cortical neurons. We find that topoisomerases selectively inhibit long genes (>100kb), with little effect on all other gene expression. Using ChIPseq against RNA Polymerase II (Pol2) we show that the Top1 inhibitor topotecan blocks transcriptional elongation of long genes specifically. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Platforms:

GPL1261 GPL17400 GPL11533

56 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html MoGene-2_1-st-v1.na33.2.mm10.transcript.csv #%create_date=Thu Mar 28 17:33:46 2013 PDT #%chip_type=MoGene-2_1-st-v1 #%lib_set_name=MoGene-2_1-st #%lib_set_version=v1 #%genome-species=Mus musculus #%genome-version=mm10 #%genome-version-ucsc=mm10 #%genome-version-ncbi=38 #%genome-version-create_date=2011-12-00 #%genome-lifted-method=liftOver #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm10 #%genome-lifted_from-version-ncbi=38 #%netaffx-annotation-date=2012-09-30 #%netaffx-annotation-netaffx-build=33 Protocol: see manufacturer's web site

Organism:

Mus musculus

214 Series

6 Related Platforms

3551 Samples

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