GEO DataSets

(Submitter supplied) MDA-MB-231 cell line with relatively high DOT1L levels was treated with two potent, selective inhibitors of the DOT1L histone methyl transferase. These compounds can inhibit cells migration and invasion and induce differentiation. Here we provide expression profiling data of cells treated with two DOT1L inhibitors [1] [2], DOT1L siRNA (siDOT1L) or control.

Organism:

Homo sapiens

Type:

Expression profiling by array

Datasets:

GDS5619 GDS5620

Platform:

GPL10558

12 Samples

Download data: TXT

Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor Compound 55 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL10558

Series:

GSE56630

8 Samples

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Analysis of MDA-MB-231 breast cancer cells treated with DOT1L (disruptor of telomeric silencing 1 like) inhibitor EPZ004777 or DOT1L siRNA. DOT1L is a histone H3-lysine79 (H3K79) methyltransferase. Results provide insight into the role of DOT1L/H3K79 methylation in breast cancer.

Organism:

Homo sapiens

Type:

Expression profiling by array, transformed count, 3 agent, 4 dose sets

Platform:

GPL10558

Series:

GSE56630

8 Samples

Download data

(Submitter supplied) The HumanHT-12 v4 Expression BeadChip provides high throughput processing of 12 samples per BeadChip without the need for expensive, specialized automation. The BeadChip is designed to support flexible usage across a wide-spectrum of experiments. The updated content on the HumanHT-12 v4 Expression BeadChips provides more biologically meaningful results through genome-wide transcriptional coverage of well-characterized genes, gene candidates, and splice variants. more...

Organism:

Homo sapiens

51 DataSets

2943 Series

4 Related Platforms

104956 Samples

Download data: TXT