GSM1532322[Accession] - GEO DataSets - NCBI

Warning: The NCBI web site requires JavaScript to function. more...

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Search results

Items: 3

Select item 2000627191.

Haploinsufficiency, but not defective paternal 5mC oxidation, accounts for the developmental defects of maternal Tet3 knockouts

(Submitter supplied) DNA demethylation of paternal genome in zygotes takes place in various mammals including mice and human. Recent studies have revealed that this is achieved through Tet3-mediated iterative oxidation of 5-methylcytosine (5mC) coupled with replication-dependent dilution. Tet3-mediated paternal DNA demethylation is believed to be required for mouse development given that Tet3 heterozygous embryos, derived by fertilizing Tet3 knockout (KO) oocytes with wild-type (WT) sperms, exhibit 5mC oxidation defects and embryonic sublethality, Here we demonstrate that the sublethality phenotype of the maternal KO mice is caused by haploinsufficiency of Tet3, but not by defective paternal 5mC oxidation. more...

Organism:: Mus musculus

Type:: Methylation profiling by high throughput sequencing

Platform:: GPL17021
10 Samples

Download data: TXT

Series

Accession:: GSE62719

ID:: 200062719

PubMed Full text in PMC Similar studies SRA Run Selector

Select item 1000170212.

Illumina HiSeq 2500 (Mus musculus)

Organism:: Mus musculus

10810 Series
294439 Samples

Platform

Accession:: GPL17021

ID:: 100017021

Select item 3015323223.

WT-Blastocyst-rep2

Organism:: Mus musculus

Source name:: WT-Blastocyst-rep2

Platform:: GPL17021
Series:: GSE62719

Download data: TXT

Sample

Accession:: GSM1532322

ID:: 301532322

SRA Run Selector

Format

Summary
Summary (text)
Unique Identifier List

Sort by

Default order
Number of Samples (High to Low)
Number of Samples (Low to High)

Send to:

Choose Destination

File
Clipboard
Collections

Supplemental Content

Filters: Manage Filters

Find related data

Search details

Important Links

Recent activity

Clear Turn Off Turn On

GSM1532322[Accession] (3)
GEO DataSets

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...

You are here: NCBI > Genes & Expression > Gene Expression Omnibus (GEO) Datasets