GSM1603219[Accession] - GEO DataSets

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Items: 4

Select item 2000656891.

Tat controls RNA Polymerase II and the epigenetic landscape to precisely rewire cellular transcriptional programs

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL16288
28 Samples

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Series

Accession:: GSE65689

ID:: 200065689

PubMed Full text in PMC Similar studies

Select item 2000656872.

Tat controls RNA Polymerase II and the epigenetic landscape to precisely rewire cellular transcriptional programs (ChIP-Seq)

(Submitter supplied) Transcription factors mediate precise regulation of gene expression programs to modulate key biological processes. In addition to controlling HIV transcription, Tat appears to modulate cellular transcription to alter the biology of target immune cells and generate a permissive state for HIV infection. However, the molecular mechanisms of transcriptional control have remained elusive. Here, we identified the direct target genes of Tat using genomics and defined mechanisms by which Tat selectively rewires cellular transcriptional programs. more...