GSM160562[Accession] - GEO DataSets

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Items: 4

Select item 2000071891.

Brain samples in a metamorphosis assay for thyroid axis disruption

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Xenopus laevis; Aquarana catesbeiana

Type:: Expression profiling by array

Platform:: GPL4800
124 Samples

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Accession:: GSE7189

ID:: 200007189

Select item 2000069642.

Expression data for brain samples in a metamorphosis assay for thyroid axis disruption - inhibitors

(Submitter supplied) Thyroid hormones (TH), thyroxine (T4) and 3, 5, 3’-triiodothyronine (T3), play crucial roles in regulation of growth, development and metabolism in vertebrates and their action are targets for endocrine disruptive agents. Perturbations in TH action can contribute to the development of disease states and the U.S. Environmental Protection Agency is developing a high throughput screen using TH-dependent amphibian metamorphosis as an assay platform. more...

Organism:: Xenopus laevis; Aquarana catesbeiana

Type:: Expression profiling by array

Platform:: GPL4800
35 Samples

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Series

Accession:: GSE6964

ID:: 200006964

Select item 1000048003.

UVicHelbing XenRanaMAGEX 434 ver1

(Submitter supplied) The protocol for designing the array is described in detail in Crump, D, Werry, K, Veldhoen, N, van Aggelen, G, and Helbing, CC (2002) Environmental Health Perspectives 110: 1199-1205. Preparation of RNA. Total RNA was obtained from preserved tadpole tissue using TRIzol reagent as described by the manufacturer (Invitrogen Canada Inc., Burlington, Ontario, Canada). We subsequently resuspended isolated RNA in RNase-free water and stored it at –70°C. more...