GSM1634863[Accession] - GEO DataSets

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Items: 4

Select item 2000671231.

Tracing the formation of hematopoietic stem cells in mouse embryos by single-cell functional and RNA-Seq analyses

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL13112
216 Samples

Download data: FPKM_TRACKING

Series

Accession:: GSE67123

ID:: 200067123

PubMed Similar studies

Select item 2000669542.

Tracing the formation of hematopoietic stem cells in mouse embryos by single-cell functional and RNA-Seq analyses [10-cell]

(Submitter supplied) Hematopoietic stem cells (HSCs) in adult are specified early from the endothelium-derived precursors (e.g., hemogenic endothelium, and pre-HSCs) in mouse mid-gestation embryos, the detailed process, however, is still largely unknown due to their rareness, transience, and current inability to prospectively isolate them efficiently . Here we developed a potent set of surface markers that could capture the earliest emerging HSCs, the CD45- pre-HSCs with high accuracy and purity, as rigorously and functionally verified by single-cell-initiated serial transplantation assays. more...