GSM1820157[Accession] - GEO DataSets

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Items: 3

Select item 2000708341.

Serotonergic regulation of melanocyte conversion: a bioelectric network explains stochastic all-or-none hyperpigmentation

(Submitter supplied) Depolarization of resting membrane potential in select cells in Xenopus larvae induces striking hyperpigmentation due to dysregulation of melanocytes. Here, we show that this non-cell-autonomous process is mediated by cAMP, CREB, and the transcription factors Sox10 and Slug. Our microarray analysis reveals specific transcripts responsive to Vmem levels within a few hours of depolarization, and a set of 517 transcripts whose expression remains altered during the full hyperpigmented phenotype over a week later, linking instructor cell-depolarization to a range of developmental processes and disease states. more...

Organism:: Xenopus laevis

Type:: Expression profiling by array

Platform:: GPL10756
4 Samples

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Accession:: GSE70834

ID:: 200070834

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000107562.

[X_laevis_2] Affymetrix Xenopus laevis Genome 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html Protocol: see manufacturer's web site