(Submitter supplied) FOXA1 is a FKHD family protein that translates epigenetic signatures at target enhancers to lineage-specific transcription and differentiation. Through genome-wide location analyses, here we show that FOXA1 expression and occupancy are, in turn, required for the maintenance of this epigenetic signature, namely DNA hypomethylation and histone 3 lysine 4 methylation. Mechanistically, this involves TET1, a 5-methylcytosine dioxygenase.
more...- Organism:
- Homo sapiens
- Type:
- Methylation profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
- Platform:
- GPL15456
- 18 Samples
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