GSM2129696[Accession] - GEO DataSets

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Items: 4

Select item 2000806021.

AML1-ETO induces leukemia via C/D box snoRNA/RNPs.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Expression profiling by array; Non-coding RNA profiling by high throughput sequencing; Expression profiling by high throughput sequencing

4 related Platforms
94 Samples

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Accession:: GSE80602

ID:: 200080602

Select item 2000805232.

Expression profile of small nucleolar RNA (snoRNA) in acute myeloid leukemia.

(Submitter supplied) Leukemogenesis requires enhanced self-renewal activity, which is induced by specific oncogenes. The underlying molecular mechanisms remain incompletely understood. We transduced mouse lineage negative bone marrow cells (enriched for hematopoietic stem and progenitor cells) with retrovirus expressing leukemic oncogene AML1-ETO9a, MYC and MLL-AF9 as well as empty vector (MIG). We found that all three oncogenes enhanced snoRNA formation. more...