U.S. flag

An official website of the United States government

Format
Sort by

Send to:

Choose Destination

Search results

Items: 3

1.

KAT–independent gene regulation by Tip60 promotes ESC self-renewal but not pluripotency

(Submitter supplied) Although histone-modifying enzymes are assumed to function in a manner dependent on their enzymatic activities, this assumption remains untested for many factors. Here we show the Tip60 (Kat5) lysine acetyltransferase (KAT), which is essential for embryonic stem cell (ESC) self-renewal and pre-implantation development, performs these functions independently of its KAT activity. Unlike ESCs depleted of Tip60, KAT–deficient ESCs exhibited minimal alterations in gene expression, chromatin accessibility at Tip60 binding sites, and self-renewal, thus demonstrating a critical KAT–independent role of Tip60 in ESC maintenance. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL21493 GPL19057 GPL13112
48 Samples
Download data: BEDGRAPH
Series
Accession:
GSE85505
ID:
200085505
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

Tip60ciMut_RNAseq_Mut2

Organism:
Mus musculus
Source name:
murine embryonic stem cells
Platform:
GPL21493
Series:
GSE85505
Download data: BEDGRAPH
Sample
Accession:
GSM2267939
ID:
302267939
Format
Sort by

Send to:

Choose Destination

Supplemental Content

db=gds|term=GSM2267939[Accession]|query=1|qty=2|blobid=MCID_66563f81e795547e5fcf401b|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
   Taxonomic Groups  [List]
Tree placeholder
    Top Organisms  [Tree]

Find related data

Search details

See more...

Recent activity

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

See more...
Support Center