GSM2292732[Accession] - GEO DataSets

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Items: 4

Select item 2000860591.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Canis lupus familiaris; Macaca mulatta; Mus musculus; Heterocephalus glaber

Type:: Methylation profiling by high throughput sequencing; Methylation profiling by genome tiling array

Platforms:: GPL13534 GPL24046 GPL22370
84 Samples

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Accession:: GSE86059

ID:: 200086059

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2000860582.

The rate of ageing-associated DNA methylation dynamics is a molecular readout of lifespan variation amongst mammalian species [Bis-PCR: dog]

(Submitter supplied) We used buccal samples from two different dog breeds with well established differences in average lifespan to perform genome-scale identification of ageing-associated differentially methylated positions (aDMPs) in a total of 48 different dogs. A significant proportion of aDMPs that gained methylation with age replicated in an independent cohort. Furthermore, we also show that human aDMPs show similar ageing-associated dynamics at the homologous genomic regions in the dog. more...