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Items: 4

1.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
23 Samples
Download data: BED, WIG, XLSX
Series
Accession:
GSE89849
ID:
200089849
2.

Id proteins suppress E2A-driven iNKT cell development prior to TCR selection [ChIP-seq]

(Submitter supplied) Id proteins have been shown to promote the differentiation of conventional αβ and γδT cells, and to suppress the expansion of invariant Natural Killer T (iNKT) cells and innate-like γδNKT within their respective cell lineages. However, it remains to be determined whether Id proteins regulate lineage specification in developing T cells that give rise to these distinct cell fates. Here we report that in the absence of Id2 and Id3 proteins, E2A prematurely activates genes critical for the iNKT cell lineage prior to TCR expression. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL21103
4 Samples
Download data: BED, WIG, XLSX
Series
Accession:
GSE89847
ID:
200089847
3.

Illumina HiSeq 4000 (Mus musculus)

Platform
Accession:
GPL21103
ID:
100021103
4.

L-DKO NKT Input

Organism:
Mus musculus
Source name:
sorted cells from thymus
Platform:
GPL21103
Series:
GSE89847 GSE89849
Download data: WIG
Sample
Accession:
GSM2391483
ID:
302391483
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Supplemental Content

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