GSM2407518[Accession] - GEO DataSets

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Items: 4

Select item 2000807431.

Identification and characterization of androgen receptor splice variants preferred bindings that drive prostate cancer progression

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing

Platform:: GPL11154
29 Samples

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Series

Accession:: GSE80743

ID:: 200080743

PubMed Full text in PMC Similar studies

Select item 2000807422.

Identification and characterization of androgen receptor splice variants preferred bindings that drive prostate cancer progression [ChIP-seq]

(Submitter supplied) Androgen receptor (AR) splice variants (ARVs) are implicated in developing castration-resistant (CR) prostate cancer (CRPC). Little is known about the ARV-mediated transcription program in CRPC. We identified ARV-preferred binding sites (ARV-PBS) and unique transcriptome in CRPC cells. ARVs preferentially bind to enhancers located in nucleosome-depleted regions with the full AR-response element (AREfull), while full-length AR (ARFL)-PBS are enhancers resided in closed chromatin regions with the composite FOXA1-nnnn-AREhalf motif. more...