GSM2463818[Accession] - GEO DataSets

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Items: 4

Select item 2001045771.

STAT5BN642H is a driver mutation for T-cell neoplasia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platforms:: GPL17021 GPL21493
20 Samples

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Series

Accession:: GSE104577

ID:: 200104577

PubMed Full text in PMC Similar studies

Select item 2000938472.

STAT5BN642H is a driver mutation for T-cell neoplasia (RNA-Seq)

(Submitter supplied) The most frequent mutation in STAT5B is the Asp642His (N642H) mutation that was found in >90 leukemic/lymphoma patients. The development of novel treatment against STAT5BN642H has been hindered by the unavailability of a suitable model and the lack of the direct causal effect of STAT5BN642H on T-cell neoplasia development. We herein demonstrate that mice expressing human STAT5BN642H in the hematopoietic compartment rapidly develop leukemia/lymphoma. more...