GEO DataSets

(Submitter supplied) Investigating gene expression patterns in mice with conditional expression of the most common RVCL mutation, V235fs, and another mice expressing a conditional C-terminal mutation, D272fs, associated with a case of human SLE. Mutations at the N-terminus affecting TREX1 DNase activity are associated with autoimmune and inflammatory conditions such as Aicardi-Goutières syndrome (AGS). Mutations in the C-terminus of TREX1 cause loss of localization to the ER and dysregulation of oligosacchryltransferase (OST) activity, and are associated with retinal vasculopathy with cerebral leukodystrophy (RVCL) and in some cases with systemic lupus erythematosus (SLE).

Organism:

Mus musculus

Type:

Expression profiling by array

Platform:

GPL18619

12 Samples

Download data: TXT

(Submitter supplied) see manufacturer's web site at http://www.agilent.com/

Organism:

Mus musculus

3 Series

46 Samples

Download data