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Items: 3

1.

RNA pol II Dynamics Modulate Co-transcriptional Chromatin Modification, CTD phosphorylation and transcriptional direction

(Submitter supplied) Using pol II mutants in human cells we found that slow transcription repositioned specific co-transcriptionally deposited chromatin modifications; H3K36me3 shifted within genes toward 5’ ends and H3K4me2 extended further upstream of start sites. Slow transcription also evoked a hyperphosphorylation of CTD Ser2 residues at 5’ ends of genes that is conserved in yeast. We propose a “dwell-time in the target zone” model to explain the effects of transcriptional dynamics on establishment of co-transcriptionally deposited protein modifications. more...
Organism:
Homo sapiens; Saccharomyces cerevisiae
Type:
Genome binding/occupancy profiling by high throughput sequencing; Other
4 related Platforms
53 Samples
Download data: BW, TDF
Series
Accession:
GSE97827
ID:
200097827

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10439 Series
180685 Samples
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Platform
Accession:
GPL11154
ID:
100011154

3.

ChIP-seq H3K36me3 WT pol II Rep2

Organism:
Homo sapiens
Source name:
HEK293 Flp-in T-REx pcDNA5 Rpb1 Amr WT
Platform:
GPL11154
Series:
GSE97827
Download data: BW
Sample
Accession:
GSM2579052
ID:
302579052

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db=gds|term=GSM2579052[Accession]|query=1|qty=3|blobid=MCID_668540358f3295570abec18e|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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