GEO DataSets

(Submitter supplied) Using pol II mutants in human cells we found that slow transcription repositioned specific co-transcriptionally deposited chromatin modifications; H3K36me3 shifted within genes toward 5’ ends and H3K4me2 extended further upstream of start sites. Slow transcription also evoked a hyperphosphorylation of CTD Ser2 residues at 5’ ends of genes that is conserved in yeast. We propose a “dwell-time in the target zone” model to explain the effects of transcriptional dynamics on establishment of co-transcriptionally deposited protein modifications. more...

Organism:

Homo sapiens; Saccharomyces cerevisiae

Type:

Genome binding/occupancy profiling by high throughput sequencing; Other

4 related Platforms

53 Samples

Download data: BW, TDF