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Items: 3

1.

A SRp55-regulated alternative splicing network controls pancreatic beta cell survival and function

(Submitter supplied) Progressive failure of insulin-producing beta cells is the central event leading to diabetes, yet the signalling networks controlling beta cell fate remain poorly understood. Here we show that SRp55, a splicing factor regulated by the diabetes susceptibility gene GLIS3, has a major role in maintaining function and survival of human beta cells. RNA-seq analysis revealed that SRp55 regulates the splicing of genes involved in cell survival and death, insulin secretion and JNK signalling. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL11154
10 Samples
Download data: GTF
Series
Accession:
GSE98485
ID:
200098485

PubMed Full text in PMC Similar studies Analyze with GEO2RSRA Run Selector

2.

Illumina HiSeq 2000 (Homo sapiens)

Organism:
Homo sapiens
10622 Series
184694 Samples
Download data
Platform
Accession:
GPL11154
ID:
100011154

3.

SRpP55 KD (siSR#2) exposed 1

Organism:
Homo sapiens
Source name:
EndoC-beta H1 human cell line
Platform:
GPL11154
Series:
GSE98485
Download data: GTF
Sample
Accession:
GSM2597310
ID:
302597310

SRA Run Selector

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db=gds|term=GSM2597310[Accession]|query=1|qty=2|blobid=MCID_678ff8d5f521160690631fa5|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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