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Items: 3

1.

Genomic and epigenomic characterization of regenerating hepatocytes

(Submitter supplied) To gain a deeper understanding of the genetic basis of liver repopulation after injury, we utilize an innovative technique to profile the expression changes and chromatin landscape during the regenerative response. We utilize the Fah-/- mouse, a model for hereditary tyrosinemia deficient in fumarylacetoacetate hydrolase (FAH), that undergoes repopulation with FAH-expressing hepatocytes. We employ translating ribosome affinity purification followed by RNA-sequencing (TRAP-seq) and assay for transposase accessible chromatin using sequencing (ATAC-seq) to specifically isolate regenerating hepatocytes and performed high-throughput sequencing to identify the dynamic genomic and epigenomic changes during liver repopulation.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL21103
26 Samples
Download data: BIGWIG, XLS
Series
Accession:
GSE109466
ID:
200109466
2.

Illumina HiSeq 2500 (Mus musculus)

Platform
Accession:
GPL17021
ID:
100017021
3.

4WeekSevere_rep1_7414

Organism:
Mus musculus
Source name:
Hepatocytes
Platform:
GPL17021
Series:
GSE109466
Download data
Sample
Accession:
GSM2943958
ID:
302943958
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db=gds|term=GSM2943958[Accession]|query=5|qty=2|blobid=MCID_673a57477d4f604c0b7a52d7|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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