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Items: 3

1.

Loss of adrenergic nerves in bone marrow drives hematopoietic stem cell niche aging

(Submitter supplied) Aging of hematopoietic stem cells (HSCs) is associated with the decline of their regenerative capacity, and multi-lineage differentiation potential, contributing to development of blood disorders. The bone marrow microenvironment was recently suggested to influence HSC aging, however the underlying mechanisms remain largely unknown. Here, we show that HSC aging critically depends on bone marrow innervation by the sympathetic nervous system (SNS), as premature loss of SNS nerves or adrenoreceptor b3 (ADRb3) signaling in the microenvironment accelerated the appearance of HSC aging phenotypes reminiscent of physiological aging. more...
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL19057
9 Samples
Download data: XLSX
Series
Accession:
GSE109546
ID:
200109546

PubMed Full text in PMC Similar studies SRA Run Selector

2.

Illumina NextSeq 500 (Mus musculus)

Organism:
Mus musculus
10195 Series
294205 Samples
Download data
Platform
Accession:
GPL19057
ID:
100019057

3.

HSC saline treated old rep3

Organism:
Mus musculus
Source name:
HSC saline treated old
Platform:
GPL19057
Series:
GSE109546
Download data
Sample
Accession:
GSM2946110
ID:
302946110

SRA Run Selector

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db=gds|term=GSM2946110[Accession]|query=8|qty=2|blobid=MCID_670cc67c475a635e85062a1f|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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