GEO DataSets

(Submitter supplied) The goal of this study was to compare the qualitative and quantitative differences in the presence of DNA:RNA hybrids (R-loops) between wild type and PrimPol knockout cell lines. Our initial genetic experiments on a reporter locus have showed a link between the formation of R-loop and non-B DNA motifs; we have therefore analysed the correlation between R-loop abundance and of sequences computationaly predicted to form triplex-DNA or G-quadruplex forming sequences, and whether this changes between the two cell lines.

Organism:

Drosophila melanogaster; Gallus gallus; Homo sapiens

Type:

Other

Platforms:

GPL24852 GPL24850 GPL24851

11 Samples

Download data: TSV

(Submitter supplied) The goal of this study was to compare the qualitative and quantitative differences in the presence of DNA:RNA hybrids (R-loops) between human wild type and PrimPol knockout human iPS cell lines. Our initial genetic experiments on a reporter locus have showed a link between the formation of R-loop and non-B DNA motifs; we have therefore analysed the correlation between R-loop abundance and of sequences computationaly predicted to form triplex-DNA or G-quadruplex forming sequences, and whether this changes between the two cell lines.

Organism:

Homo sapiens; Gallus gallus

Type:

Other

Platform:

GPL24850

3 Samples

Download data: TSV