GEO DataSets

(Submitter supplied) Background: Survival and function of insulin-secreting pancreatic β-cells are markedly altered by changes in nutrient availability. In vitro, culture in 10 rather than 2mM glucose improves rodent β-cell survival and function whereas glucose concentrations above 10mM are deleterious. Aim-Method: To identify the mechanisms of such β-cell plasticity, we tested the effects of a 18h culture at 2, 5, 10 and 30mM glucose on the transcriptome of rat islets precultured for 1 week at 10mM glucose (Affymetrix Rat 230.2 arrays). more...

Organism:

Rattus norvegicus

Type:

Expression profiling by array

Dataset:

GDS3529

Platform:

GPL1355

16 Samples

Download data: CEL, EXP

Analysis of pancreatic islets cultured for 18 hours in 2, 5, 10, or 30 mM glucose. Culture in 2 to 10 mM glucose improves beta cell survival and function, while concentrations above 10 mM are deleterious. Results provide insight into the molecular basis of this sensitivity to glucose concentrations.

Organism:

Rattus norvegicus

Type:

Expression profiling by array, count, 4 dose sets

Platform:

GPL1355

Series:

GSE12817

16 Samples

Download data: CEL, EXP

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 27, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site The GeneChip Rat Genome 230 2.0 Array is a powerful tool for toxicology, neurobiology, and other applications using rat as a model organism. more...

Organism:

Rattus norvegicus

107 DataSets

749 Series

13 Related Platforms

23057 Samples

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