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GEO DataSets

Functional Genomics Studies

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Items: 4

Select item 2001167341.

Initial host response to mycobacterial infection is orchestrated through H3K4 methylation-mediated RNA polymerase II binding at key immune function genes.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Bos taurus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Non-coding RNA profiling by high throughput sequencing

Platforms:: GPL23295 GPL19172
30 Samples

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Accession:: GSE116734

ID:: 200116734

PubMed Full text in PMC Similar studies

Select item 2001167312.

Initial host response to mycobacterial infection is orchestrated through H3K4 methylation-mediated RNA polymerase II binding at key immune function genes [ChIP-seq]

(Submitter supplied) Massive reprogramming of the host alveolar macrophage transcriptome occurs during the initial stages of tuberculosis. In bovine tuberculosis, Mcobacterium bovis can persist and replicate within alveolar macrophages through varied mechanisms to subvert or exploit host immune responses ( REF). To determine how these transcriptional changes are regulated we performed ChIPseq analysis of H3K4 and H3K27 methylation, established histone tail markers associated with permissive and repressive chromatin states, respectively. more...