GSM3347569[Accession] - GEO DataSets

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Items: 3

Select item 2001187851.

H3K36me2 recruits DNMT3A and shapes intergenic DNA methylation landscapes

(Submitter supplied) Enzymes catalyzing CpG methylation in DNA, including DNMT1 and DNMT3A/B, are indispensable for mammalian tissue development and homeostasis. They are also implicated in human developmental disorders and cancers, supporting a critical role of DNA methylation during cell fate specification and maintenance. Recent studies suggest that histone post-translational modifications (PTMs) are involved in specifying patterns of DNMT localization and DNA methylation at promoters and actively transcribed gene bodies. more...

Organism:: Homo sapiens; Mus musculus; Drosophila melanogaster

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing