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Items: 3

1.

Single-cell profiling of the myeloid landscape identifies cell subsets with distinct fates during neuroinflammation

(Submitter supplied) The innate immune cell compartment is highly diverse in the healthy central nervous system (CNS) including parenchymal and non-parenchymal macrophages. However, this complexity is increased in inflammatory settings by the recruitment of circulating myeloid cells. It is unclear which disease-specific myeloid subsets exist and what their transcriptional profiles and dynamics during CNS pathology are. By combining deep single-cell transcriptome analysis, fate mapping, in vivo imaging, clonal analysis, and transgenic lines, we comprehensively characterized unappreciated myeloid subsets in several CNS compartments during neuroinflammation. During inflammation, CNS macrophage subsets undergo self-renewal, and random proliferation shifted towards clonal expansion. Finally, functional studies demonstrated that endogenous CNS tissue macrophages are redundant for antigen presentation. Our results highlight myeloid cell diversity and provide insights into the brain’s innate immune system.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing
Platform:
GPL21493
55 Samples
Download data: CSV
Series
Accession:
GSE118948
ID:
200118948
2.

Illumina HiSeq 3000 (Mus musculus)

Platform
Accession:
GPL21493
ID:
100021493
3.

PV2_Acute_2_6

Organism:
Mus musculus
Source name:
Perivascular space and parenchyma, peak phase
Platform:
GPL21493
Series:
GSE118948
Download data: CSV
Sample
Accession:
GSM3351744
ID:
303351744
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