GSM3465057[Accession] - GEO DataSets

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Items: 4

Select item 2001223661.

MeCP2 regulates genome-wide gene expression through recognition of H3K27me3

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Mus musculus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by array; Methylation profiling by high throughput sequencing

4 related Platforms
43 Samples

Download data: BW, RCC, TXT

Series

Accession:: GSE122366

ID:: 200122366

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 2001223632.

MeCP2 regulates genome-wide gene expression through recognition of H3K27me3 [ChIP_mouse]

(Submitter supplied) MeCP2 plays a multifaceted role in gene expression regulation and chromatin organization. Interaction between MeCP2 and methylated DNA to regulate gene expression is well established. However, the widespread MeCP2 distribution suggests its additional interactions with chromatin. Here we show, by both biochemical and ChIP-seq analyses, that MeCP2 directly binds to nucleosome subunit proteins and is recruited to distinct chromatin regions where H3K27me3 is enriched. more...