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Items: 4

1.

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL20301
116 Samples
Download data: BIGWIG, NARROWPEAK
Series
Accession:
GSE125221
ID:
200125221

2.

Histone chaperone CAF-1 is a synthetic lethal vulnerability in the context of ARID1A deficiencies [RNA-Seq]

(Submitter supplied) Mutations in the BAF chromatin remodeling complex rank among the most frequent genetic alterations in human cancers, many of which result in a loss of function of the respective subunits. Recent genomic and chemical screens have revealed synthetic lethal interactions of BAF complex subunits with each other as well as with further chromatin modifiers. Using an epigenome-focused shRNA library, we identified loss of the histone chaperone complex CAF-1 (chromatin assembly factor 1) as a synthetic lethal vulnerability of ARID1A-deficient cells that is enhanced by the androgen receptor agonist testosterone. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL20301
36 Samples
Download data: CSV
Series
Accession:
GSE125219
ID:
200125219

Analyze with GEO2RSRA Run Selector

3.

Illumina HiSeq 4000 (Homo sapiens)

Organism:
Homo sapiens
8491 Series
195008 Samples
Download data
Platform
Accession:
GPL20301
ID:
100020301

4.

HAP1_RNA-seq_WT_Control_r5

Organism:
Homo sapiens
Source name:
cell line
Platform:
GPL20301
Series:
GSE125219 GSE125221
Download data
Sample
Accession:
GSM3566492
ID:
303566492

SRA Run Selector

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db=gds|term=GSM3566492[Accession]|query=14|qty=2|blobid=MCID_6733e19d3ec0a11b447e3b42|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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