GSM3640278[Accession] - GEO DataSets

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Items: 4

Select item 2001278631.

ERα over-expression does not accelerate development of p53-deficient mammary tumors in mice

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens; Mus musculus

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL17021 GPL16791
26 Samples

Download data: BED

Series

Accession:: GSE127863

ID:: 200127863

PubMed Similar studies

Select item 2001278622.

ERα over-expression does not accelerate development of p53-deficient mammary tumors in mice [RNA-Seq]

(Submitter supplied) About 75% of all breast cancers express the nuclear hormone receptor oestrogen receptor α (ERα). However, the majority of mammary tumors from genetically engineered mouse models are ERα-negative. To model ERα-positive breast cancer in mice, we exogenously introduced expression of mouse and human ERα in an existing p53-deficiency driven breast cancer mouse model. After initial ERα expression during development of the mammary gland, expression was reduced or lost in adult glands and p53-deficient mammary tumors. more...