GSM3680196[Accession] - GEO DataSets

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Items: 4

Select item 2001285681.

X chromosome domain architecture regulates Caenorhabditis elegans lifespan but not dosage compensation

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Caenorhabditis elegans

Type:: Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other

Platform:: GPL22765
26 Samples

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Accession:: GSE128568

ID:: 200128568

PubMed Full text in PMC Similar studies

Select item 2001285642.

X chromosome domain architecture regulates Caenorhabditis elegans lifespan but not dosage compensation [ChIP-seq]

(Submitter supplied) Mechanisms establishing higher-order chromosome structures and their roles in gene regulation are elusive. We analyzed chromosome architecture during nematode X-chromosome dosage compensation, which represses transcription via a dosage-compensation condensin complex (DCC) that binds hermaphrodite Xs and establishes megabase-size topologically associating domains (TADs). We show that DCC binding at high-occupancy sites (rex sites) defines eight TAD boundary locations. more...