GSM374006[Accession] - GEO DataSets

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Items: 3

Select item 2000144571.

Rb deletion in mammary stem/progenitor epithelium induces tumors with features of luminal-B or basal-like breast cancer

(Submitter supplied) The retinoblastoma tumor suppressor, Rb, is implicated in luminal-B and basal-like breast carcinomas, yet its effect on mammary gland development and causal role in breast cancer subtypes remain undefined. Here we show that conditional deletion of Rb in mouse mammary epithelium led to expansion of the stem/progenitor cells and to focal acinar hyperplasia with squamous metaplasia. These uniform lesions progressed into histologically diverse, transplantable mammary adenocarcinomas and adenosquamous carcinomas with features of luminal-B or basal-like carcinomas. more...

Organism:: Mus musculus

Type:: Expression profiling by array

Platforms:: GPL4092 GPL891 GPL2881
144 Samples

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Accession:: GSE14457

ID:: 200014457

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000040922.

Agilent-014695 Mouse Genome CGH Microarray 244A (G4415A) (Feature Number version)

(Submitter supplied) This microarray is Agilent’s premium product for mouse DNA copy-number profiling. Over 235,000 60-mer oligonucleotide probes, specifically optimized for copy-number measurement, span coding and non-coding genomic sequences with median spacing of 6.2 kb and 15.2 kb respectively. This microarray is designed for use with Agilent’s optimized assay protocols, enabling researchers to use nanogram levels of total genomic DNA without complexity reduction. more...