GSM4077845[Accession] - GEO DataSets

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Items: 4

Select item 2001549291.

A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
26 Samples

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Accession:: GSE154929

ID:: 200154929

PubMed Full text in PMC Similar studies

Select item 2001373802.

A distinct CD38+CD45RA+ population of CD4+, CD8+ and double-negative T cells is controlled by FAS (I)

(Submitter supplied) The identification and characterization of rare immune cell populations in humans can be facilitated by their growth advantage in the context of specific genetic diseases. Here, we use autoimmune-lymphoproliferative syndrome to identify a population of FAS-controlled TCRab+ T cells. They include CD4+, CD8+ and double-negative T cells and can be defined by a CD38+CD45RA+T-BET- expression pattern. These unconventional T cells are present in all healthy individuals, generated before birth, enriched in lymphoid tissue and do not expand during acute viral infection. more...