GSM4094899[Accession] - GEO DataSets

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Items: 4

Select item 2001379581.

Transcriptional silencers in Drosophila serve a dual role as transcriptional enhancers in alternate cellular contexts

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Drosophila melanogaster

Type:: Other

Platforms:: GPL17275 GPL21306
34 Samples

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Series

Accession:: GSE137958

ID:: 200137958

PubMed Full text in PMC Similar studies

Select item 2001379492.

Transcriptional silencers in Drosophila serve a dual role as transcriptional enhancers in alternate cellular contexts [HiChIP]

(Submitter supplied) Silencers active in the Drosophila embryonic mesoderm were identified by reporter assays in dissociated embryonic cells. We find that, despite the presence of ChIP peaks for known transcriptional corepressors and marks of repressed chromatin, the only significantly enriched source of mesodermal silencers is non-mesodermal enhancers. We present evidence that a subset of silencers acts by looping to target promoters.