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Items: 4

1.

Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
Platform:
GPL20795
74 Samples
Download data: BED, BEDGRAPH, CSV
Series
Accession:
GSE147286
ID:
200147286
2.

Three-dimensional genome architectural CCCTC-binding factor makes choice in duplicated enhancers at Pcdhα locus. [4C-seq]

(Submitter supplied) By CRISPR/Cas9 DNA-fragment editing, in conjunction with chromosome conformation capture, ChIP-seq and RNA-seq technology, we studied CRISPR single cell clones of duplicated CBS-containing enhancers or promoters in the Pcdhα gene cluster. We found that CTCF plays an essential role in determining promoter choice and enhancer selection. In addition, the choices mediated by CTCF is based on the chromatin loops formed between forward-reverse convergent CBS pairs with the proximal one dominant.
Organism:
Homo sapiens
Type:
Other
Platform:
GPL20795
46 Samples
Download data: BEDGRAPH
Series
Accession:
GSE147274
ID:
200147274
3.

HiSeq X Ten (Homo sapiens)

Platform
Accession:
GPL20795
ID:
100020795
4.

4C_HS51_mE2_CBSmut_rep2

Organism:
Homo sapiens
Source name:
HEC-1-B
Platform:
GPL20795
Series:
GSE147274 GSE147286
Download data: BEDGRAPH
Sample
Accession:
GSM4423268
ID:
304423268
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Supplemental Content

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