GSM4675951[Accession] - GEO DataSets

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Items: 3

Select item 2001546191.

Long-term treatment with senolytic drugs Dasatinib and Quercetin ameliorates age-dependent intervertebral disc degeneration in mice

(Submitter supplied) Intervertebral disc degeneration is highly prevalent in the elderly population and is a leading cause of chronic back pain and disability. Studies have linked degenration with increased disc cell senescence. Likewise, senolytics such as Dasatinib + Quercetin combination may provide a novel approach to mitigate age-dependnt disc degeneration. We used microarrays to explore the transcriptomics of differentially expressed genes between aged disc compartments: AF vs NP at 23M, AF: D+Q vs Veh and NP: D+Q vs Veh.

Organism:: Mus musculus

Type:: Expression profiling by array

Platform:: GPL23038
18 Samples

Download data: CEL, CHP

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Accession:: GSE154619

ID:: 200154619

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000230382.

[Clariom_S_Mouse] Affymetrix Clariom S Assay, Mouse (Includes Pico Assay)

(Submitter supplied) This platform supports submissions for: Clariom S Assay: https://www.thermofisher.com/order/catalog/product/902930 Clariom S Pico Assay: https://www.thermofisher.com/order/catalog/product/902933 Annotations: #%lib_set_version=r1 #%genome-species=Mus musculus #%genome-version=mm10 #%genome-version-ucsc=mm10 #%genome-version-ncbi=38 #%genome-version-create_date=2011-12-00 #%genome-lifted-method=psl-map.pl #%genome-lifted_from-species=Mus musculus #%genome-lifted_from-version-ucsc=mm10 #%genome-lifted_from-version-ncbi=38 #%netaffx-annotation-date=2016-06-03 #%netaffx-annotation-netaffx-build=36 Protocol: See manufacturer's web site (www.affymetrix.com).