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Items: 4

1.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Methylation profiling by genome tiling array; Genome binding/occupancy profiling by high throughput sequencing; Methylation profiling by high throughput sequencing; Expression profiling by high throughput sequencing
4 related Platforms
259 Samples
Download data: IDAT, TAB
Series
Accession:
GSE155339
ID:
200155339

PubMed Full text in PMC Similar studies

2.

Aging of preleukemic thymocytes drives CpG island hypermethylation in T-cell acute lymphoblastic leukemia [EPICarray_PDX]

(Submitter supplied) Cancer cells display DNA hypermethylation at specific CpG islands in comparison to their normal healthy counterparts, but the mechanism that drives this so-called CpG island methylator phenotype (CIMP) remains poorly understood. Here, we show that CpG island methylation in human T-cell acute lymphoblastic leukemia (T-ALL) mainly occurs at promoters of PRC2 target genes that are not expressed in normal or malignant T-cells and which display a reciprocal association with H3K27me3 binding. more...
Organism:
Homo sapiens
Type:
Methylation profiling by genome tiling array
Platform:
GPL23976
12 Samples
Download data: IDAT, TXT
Series
Accession:
GSE155334
ID:
200155334

3.

Illumina Infinium HumanMethylation850 BeadChip

(Submitter supplied) See manufacturer's website
Organism:
Homo sapiens
281 Series
1 Related Platform
16960 Samples
Download data
Platform
Accession:
GPL23976
ID:
100023976

4.

PDX T-ALL 2 Control Rep3 EPICarray

Organism:
Homo sapiens
Source name:
T-ALL blasts from PDX spleen
Platform:
GPL23976
Series:
GSE155334 GSE155339
Download data: IDAT
Sample
Accession:
GSM4699376
ID:
304699376

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