GSM512906[Accession] - GEO DataSets

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Items: 3

Select item 2000204521.

Profiling of H3K9me3 levels predicts Transcription Factor Activity and Survival in Acute Myeloid Leukemia

(Submitter supplied) Acute Myeloid Leukemia (AML) is commonly associated with alterations in transcription factors due to altered expression or gene mutations. These changes might induce leukemia specific patterns of histone modifications. We used ChIP-Chip to analyze histone H3 Lysine 9 trimethylation (H3K9me3) patterns in primary AML (n=108), ALL (n=28), CD34+ cells (n=21) and white blood cells (n=15) specimens. Hundreds of promoter regions in AML showed significant alterations in H3K9me3 levels. more...

Organism:: Homo sapiens

Type:: Genome binding/occupancy profiling by genome tiling array

Platform:: GPL10087
172 Samples

Download data: GPR

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Accession:: GSE20452

ID:: 200020452

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000100872.

UniMuenster-HomoSapiens-30K-Promoter_v1

(Submitter supplied) Human putative promoter sequences of all known genes and sca/miRNA genes were downloaded from UCSC Golden Path Database based on NCBI Build 35. The putative promoter sequences were defined as 2,000 bases upstream and 1,000 bases downstream from transcription start site. Sequences were repeat-masked. Probes were designed from the sense strand of the non-repeat-masked portions of the promoter regions, with these probe restrictions: 1) Length: 46 – 55 bases 2) Tm: 69 – 79 °C 3) Creatable by NimbleGen in 148-rounds of A, C, G, T. more...