GSM5151460[Accession] - GEO DataSets

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Items: 4

Select item 2001686341.

Targeted single-cell RNA sequencing of transcription factors facilitates biological insights from human cell experimental models

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platform:: GPL20301
1756 Samples

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Accession:: GSE168634

ID:: 200168634

PubMed Full text in PMC Similar studies

Select item 2001686262.

Targeted single cell RNA-sequencing of transcription factors facilitates biological insights from human cell experimental models [intestinal stromal cells pre-capture]

(Submitter supplied) Single cell RNA sequencing (scRNA-seq) is a widely used method for identifying cell types and trajectories in biologically heterogeneous samples, but is limited in its detection and quantification of lowly expressed genes. This results in missing important biological signals, such as the expression of key transcription factors (TFs) driving cellular differentiation. We show that targeted sequencing of ~1000 TFs (scCapture-seq) in iPSC-derived neuronal cultures greatly improves the biological information garnered from scRNA-seq. more...