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Items: 4

1.

A myeloid maturation program initiated by nucleotide depletion during S phase [ATAC-Seq]

(Submitter supplied) Certain cancers, such as acute myeloid leukemia (AML), are caused by malignant stem cells that fail maturation. We sought to mechanistically understand how metabolism might regulate cell fate decisions and to identify metabolic differentiation agents that might be leveraged therapeutically.  We find that nucleotide – purine, pyrimidine, and deoxynucleotide – depletion leads to AML differentiation by way of replication stress. more...
Organism:
Homo sapiens; Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platforms:
GPL17021 GPL18573 GPL19057
48 Samples
Download data: BW
Series
Accession:
GSE172299
ID:
200172299

PubMed Similar studies SRA Run Selector

2.

Nucleotide depletion promotes cell fate transitions by inducing DNA replication stress

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens; Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing; Other
5 related Platforms
284 Samples
Download data: BW, CSV, MTX, TXT
Series
Accession:
GSE172335
ID:
200172335

PubMed Similar studies

3.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11049 Series
298474 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

4.

633_E2wd8_rep2_ATACseq

Organism:
Mus musculus
Source name:
63.3 mouse GMP cells
Platform:
GPL17021
Series:
GSE172299 GSE172335
Download data: BW
Sample
Accession:
GSM5252109
ID:
305252109

SRA Run Selector

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db=gds|term=GSM5252109[Accession]|query=1|qty=3|blobid=MCID_670f73d3c7d3ca20d5315f78|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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