GSM5291268[Accession] - GEO DataSets

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Items: 4

Select item 2001743701.

Muscle group specific transcriptomic and DNA methylation differences related to developmental patterning influence FSHD

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing; Methylation profiling by high throughput sequencing

Platform:: GPL18573
92 Samples

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Series

Accession:: GSE174370

ID:: 200174370

Select item 2001743012.

Muscle group specific transcriptomic and DNA methylation differences related to developmental patterning influence FSHD [expression]

(Submitter supplied) Muscle groups throughout the body are specialized in function and are specified during development by position specific gene regulatory networks. In developed tissue, myopathies affect muscle groups differently. Facioscapulohumeral muscular dystrophy, FSHD, affects upper body and tibialis anterior (TA) muscles earlier and more severely than others such as quadriceps. To investigate an epigenetic basis for susceptibility of certain muscle groups to disease, we perform DNA methylation and RNA sequencing on primary patient derived myoblasts from TA and quadricep for both control and FSHD2 as well as RNA-seq for myoblasts from FSHD1 deltoid, bicep and TA over a time course of differentiation. more...