GSM540553[Accession] - GEO DataSets

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Items: 3

Select item 2000216601.

Advancing a Clinically Relevant Perspective of the Clonal Nature of Cancer

(Submitter supplied) We used DNA content-based flow cytometry to distinguish and isolate nuclei from clonal populations in primary tissues from three disparate cancers with variable clinical histories. We then developed a methodology to adapt flow cytometrically purified nuclei samples for use with whole genome technologies including aCGH and next generation sequencing (NGS). Our results demonstrate that selected aberrations in the genomes of distinct clonal populations in each patient create clinically relevant contexts at least with respect to the cancer types profiled in this study.

Organism:: Homo sapiens

Type:: Genome variation profiling by genome tiling array

Platform:: GPL4091
61 Samples

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Accession:: GSE21660

ID:: 200021660

PubMed Full text in PMC Similar studies Analyze with GEO2R

Select item 1000040912.

Agilent-014693 Human Genome CGH Microarray 244A (Feature number version)

(Submitter supplied) This microarray is Agilent’s premium product for human DNA copy-number profiling. Over 236,000 60-mer oligonucleotide probes, specifically optimized for copy-number measurement, span coding and non-coding genomic sequences with median spacing of 7.4 kb and 16.5 kb respectively. This microarray is designed for use with Agilent’s optimized assay protocols, enabling researchers to use nanogram levels of total genomic DNA without complexity reduction. more...