GSM5602454[Accession] - GEO DataSets

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Items: 4

Select item 2001849611.

THAP1 is cell type dependent regulator of SP1 family crucial for dystonic syndromes in human and rat

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Rattus norvegicus; Homo sapiens

Type:: Genome binding/occupancy profiling by high throughput sequencing; Expression profiling by high throughput sequencing

Platforms:: GPL25947 GPL24676
30 Samples

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Series

Accession:: GSE184961

ID:: 200184961

PubMed Full text in PMC Similar studies

Select item 2001849582.

THAP1 is cell type dependent regulator of SP1 family crucial for dystonic syndromes in human and rat [SHSY5Y_RNA-seq]

(Submitter supplied) THAP1 is a transcription factor and its mutations are responsible for DYT6 dystonia. However, how THAP1 mutations lead to these gene expression alterations and whether the gene expression changes are also reflected in the brain of THAP1 patients are still unclear. In this study we used epigenetic and transcriptomic approaches combined with multiple model systems to uncover the function of THAP1 and the potential pathogenesis of DYT6 dystonia. more...