GEO DataSets

(Submitter supplied) Sle2c1 is an NZM2410-derived lupus susceptibility locus that induces an expansion of the B1a cell compartment. B1a cells have a repertoire enriched for autoreactivity, and an expansion of this B cell subset occurs in several mouse models of lupus. Here we showed that expression of Sle2c1 enhances NZB cellular phenotypes that have been associated with autoimmune pathogenesis. A combination of genetic mapping and candidate gene analysis presents Cdkn2c, a gene encoding for cyclin kinase inhibitor p18INK4c (p18), as the top candidate gene for inducing the Slec2c1 associated expansion of B1a cells. more...

Organism:

Mus musculus

Type:

Expression profiling by array

Dataset:

GDS4191

Platform:

GPL1261

16 Samples

Download data: CEL

Analysis of peritoneal cavity B cells (B1a) and splenic B (sB) cells from B6.Sle2c1 mice. Sle2 induces expansion of the B1a cell compartment, a B cell defect consistently associated with lupus. Results provide insight into molecular mechanisms underlying susceptibility to lupus in the NZM2410 model.

Organism:

Mus musculus

Type:

Expression profiling by array, transformed count, 2 cell type, 2 strain sets

Platform:

GPL1261

Series:

GSE23114

16 Samples

Download data: CEL

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 07, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site All probe sets represented on the GeneChip Mouse Expression Set 430 are included on the GeneChip Mouse Genome 430 2.0 Array. more...

Organism:

Mus musculus

601 DataSets

4546 Series

40 Related Platforms

58941 Samples

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