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Items: 4

1.

Single-cell and spatial architecture of human tissue granulomas reveals an aberrant immune-regulatory program underlying sarcoidosis [single-cell sequencing]

(Submitter supplied) Purpose: Granulomas are lumps of immune cells that can form in various organs, causing chronic inflammation and tissue destruction. While most granulomas appear histologically heterogeneous and unstructured, they have a certain resemblance of lymphoid organ formation. We thus pursued the hypothesis that granuloma formation is a highly orchestrated process that mixes and repurposes various regulatory mechanisms of normal development Methods: We performed single-cell sequencing and spatial transcriptomics on granulomas from patients diagnosed with cutaneous sarcoidosis, and we bioinformatically reconstructed their gene-regulatory networks and cell-cell interactions Results: We observed regulatory processes underlying granuloma formation that were highly conserved across individuals and followed characteristic spatial patterns. more...
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27644
36 Samples
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Series
Accession:
GSE192456
ID:
200192456
2.

Single-cell and spatial architecture of human tissue granulomas reveals an aberrant immune-regulatory program underlying sarcoidosis

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Homo sapiens
Type:
Expression profiling by high throughput sequencing
Platform:
GPL27644
57 Samples
Download data
Series
Accession:
GSE192461
ID:
200192461
3.

Illumina Novaseq 6000 (Homo sapiens)

Organism:
Homo sapiens
26 Series
680 Samples
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Platform
Accession:
GPL27644
ID:
100027644
4.

Patient P04 Non-lesional skin sample taken at visit V06

Organism:
Homo sapiens
Source name:
Healthy skin cell suspension
Platform:
GPL27644
Series:
GSE192456 GSE192461
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Sample
Accession:
GSM5747389
ID:
305747389
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Supplemental Content

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