GEO DataSets

(Submitter supplied) Aneuploidy is a hallmark of human cancers, but most mouse cancer models lack the extensive aneuploidy seen in many human tumors. The zebrafish is becoming an increasingly popular model for studying cancer. Here we report that malignant peripheral nerve sheath tumors (MPNSTs) that arise in zebrafish as a result of mutations in either ribosomal protein (rp) genes or in p53 are highly aneuploid. Karyotyping reveals that these tumors frequently harbor near-triploid numbers of chromosomes, and they vary in chromosome number from cell-to-cell within a single tumor. more...

Organism:

Danio rerio

Type:

Genome variation profiling by array; Genome variation profiling by high throughput sequencing

Platforms:

GPL10797 GPL9319

48 Samples

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