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Items: 4

1.

Recapitulation of human premature aging by using iPSCs from Hutchinson-Gilford progeria syndrome

(Submitter supplied) Hutchinson-Gilford progeria syndrome (HGPS) is a rare and fatal human premature aging disease1-5, characterized by premature atherosclerosis and degeneration of vascular smooth muscle cells (SMCs)6-8. HGPS is caused by a single-point mutation in the LMNA gene, resulting in the generation of progerin, a truncated mutant of lamin A. Accumulation of progerin leads to various aging-associated nuclear defects including disorganization of nuclear lamina and loss of heterochromatin9-12. more...
Organism:
Homo sapiens
Type:
Expression profiling by array
Dataset:
GDS3892
Platform:
GPL570
10 Samples
Download data: CEL
Series
Accession:
GSE24487
ID:
200024487

PubMed Full text in PMC Similar studies Analyze with GEO2R

2.
Full record GDS3892

Induced pluripotent stem cell-based accelerated aging model

Analysis of iPSCs generated from fibroblasts from patients with Hutchinson-Gilford progeria syndrome (HGPS), a rare and fatal premature aging disease. Premature aging was recapitulated by differentiation of the HGPS-iPSCs. Results provide insight into molecular mechanisms underlying premature aging.
Organism:
Homo sapiens
Type:
Expression profiling by array, transformed count, 3 cell line, 2 genotype/variation sets
Platform:
GPL570
Series:
GSE24487
10 Samples
Download data: CEL
DataSet
Accession:
GDS3892
ID:
3892

PubMed Full text in PMC Similar studies GEO Profiles Analyze DataSet

3.

[HG-U133_Plus_2] Affymetrix Human Genome U133 Plus 2.0 Array

(Submitter supplied) Affymetrix submissions are typically submitted to GEO using the GEOarchive method described at http://www.ncbi.nlm.nih.gov/projects/geo/info/geo_affy.html June 03, 2009: annotation table updated with netaffx build 28 June 06, 2012: annotation table updated with netaffx build 32 June 23, 2016: annotation table updated with netaffx build 35 Protocol: see manufacturer's web site Complete coverage of the Human Genome U133 Set plus 6,500 additional genes for analysis of over 47,000 transcripts All probe sets represented on the GeneChip Human Genome U133 Set are identically replicated on the GeneChip Human Genome U133 Plus 2.0 Array. more...
Organism:
Homo sapiens
602 DataSets
5669 Series
61 Related Platforms
174579 Samples
Download data
Platform
Accession:
GPL570
ID:
100000570

4.

BJ-iPSC replicate 1

Organism:
Homo sapiens
Source name:
BJ-iPSC_1
Platform:
GPL570
Series:
GSE24487
Dataset:
GDS3892
Download data: CEL
Sample
Accession:
GSM603050
ID:
300603050

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