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Items: 4

1.

A single amino acid at the PNT domain of ERG mediates its leukemogenic activity through interaction with the NCoR-HDAC3 co-repressor complex.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.
Organism:
Mus musculus
Type:
Expression profiling by high throughput sequencing; Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
49 Samples
Download data: BW
Series
Accession:
GSE200393
ID:
200200393

PubMed Full text in PMC Similar studies

2.

The NCOR-HDAC3 co-repressive complex modulates the leukemogenic potential of ERG.

(Submitter supplied) The ETS transcription factor ERG is involved in several cancers including leukemia. However, ERG domains and co-factors involved in leukemogenesis remain largely uncharacterized and as a transcription factor it is currently undruggable. Here, we report a critical role for the conserved amino-acid proline at position 199, at the 3’ end of the PNT domain, for ERG’s leukemogenic activity. Specifically, we demonstrate that it is required for ERG-induced self-renewal and restriction of myeloid differentiation in hematopoietic progenitor cells and for initiation of leukemia in mouse transduction/transplantation models. more...
Organism:
Mus musculus
Type:
Genome binding/occupancy profiling by high throughput sequencing
Platform:
GPL17021
16 Samples
Download data: BW, XLSX
Series
Accession:
GSE200389
ID:
200200389

PubMed Full text in PMC Similar studies

3.

Illumina HiSeq 2500 (Mus musculus)

Organism:
Mus musculus
11054 Series
298532 Samples
Download data
Platform
Accession:
GPL17021
ID:
100017021

4.

ERG_P199L_H3K4me3

Organism:
Mus musculus
Source name:
Hoxb8-ER cells
Platform:
GPL17021
Series:
GSE200389 GSE200393
Download data: BW
Sample
Accession:
GSM6032533
ID:
306032533

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db=gds|term=GSM6032533[Accession]|query=3|qty=2|blobid=MCID_6713cf8bc7d3ca20d55e2147|ismultiple=true|min_list=5|max_list=20|def_tree=20|def_list=|def_view=|url=/Taxonomy/backend/subset.cgi?|trace_url=/stat?
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  • GSM6032533[Accession] (4)
    GEO DataSets
  • Sugars
    Sugars
    Short chain carbohydrate molecules that have hydroxyl groups attached to each carbon atom unit with the exception of one carbon that has a doubly-bond aldehyde or ketone oxyge...<br/>Year introduced: 2018
    MeSH

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