GSM6106269[Accession] - GEO DataSets

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Items: 4

Select item 2002032651.

PAX4 loss of function alters human endocrine cell development and influences diabetes risk.

(Submitter supplied) This SuperSeries is composed of the SubSeries listed below.

Organism:: Homo sapiens

Type:: Expression profiling by high throughput sequencing

Platforms:: GPL20301 GPL24676
232 Samples

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Accession:: GSE203265

ID:: 200203265

PubMed Full text in PMC Similar studies

Select item 2002022062.

PAX4 loss of function alters human endocrine cell development and influences diabetes risk [dateset 1]

(Submitter supplied) Diabetes is a major chronic disease with an excessive healthcare burden on society. A coding variant (p.Arg192His) in the transcription factor PAX4 is uniquely and reproducibly associated with altered risk for type 2 diabetes (T2D) in East Asian populations, whilst rare PAX4 alleles have been proposed to cause monogenic diabetes8. In mice, Pax4 is essential for beta cell formation but neither the role of diabetes-associated variants in PAX4 nor PAX4 itself on human beta cell development and/or function are known. more...